Bone augmentation for cancellous bone-development of a new animal model

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Bone augmentation for cancellous bone- development of a new animal model

BACKGROUND Reproducible and suitable animal models are required for in vivo experiments to investigate new biodegradable and osteoinductive biomaterials for augmentation of bones at risk for osteoporotic fractures. Sheep have especially been used as a model for the human spine due to their size and similar bone metabolism. However, although sheep and human vertebral bodies have similar biomecha...

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Appropriate well-characterized bone defect animal models remain essential for preclinical research. This pilot study demonstrates a relevant animal model for cancellous bone defect healing. Three different defect diameters (8, 11, 14 mm) of fixed depth (25 mm) were compared in both skeletally immature (18-month-old) and aged sheep (5-year-old). In each animal, four defects were surgically creat...

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ژورنال

عنوان ژورنال: BMC Musculoskeletal Disorders

سال: 2013

ISSN: 1471-2474

DOI: 10.1186/1471-2474-14-200